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Publications

Throughout the years our lab has managed to publish a multitude of our projects since it has been funded in 2014. Here you can find a list with all our publications.

2023

Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study.

Aousji O, Feldengut S, Antonucci S, Schön M, Boeckers TM, Matschke J, Mawrin C, Ludolph AC, Del Tredici K, Roselli F, Braak H.

Acta Neuropathol Commun. 2023 Jul25; 11(1):120.

SRF deletion results in earlier disease onset in a mouse model of amyotrophic lateral sclerosis.

Song J, Dikwella NY, Sinske D, Roselli F, Knöll B.

JCI Insight. 2023 Jun20; e167694.

Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model.

Olde Heuvel F, Ouali Alami N, Aousji O, Pogatzki-Zahn E, Zahn PK, Wilhelm H, Deshpande D, Khatamsaz E, Catanese A, Woelfle S, Schön M, Grabrucker S, Ludolph AC, Verpelli C, Michaelis J, Boeckers TM, Roselli F.

Mol Autism. 2023 Jun14; 14(1):21

CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue.

Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, Deisseroth K, Michaelis J, Boeckers TM, Schön M.

BMC Biol. 2023 May24; 21(1):113.

CSF oligoclonal IgG bands are not associated with ALS progression and prognosis.

Klose V, Jesse S, Lewerenz J, Kassubek J, Dorst J, Tumani H, Ludolph AC, Roselli F.

Front Neurol. 2023 May24; 5;14:1170360.

Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis.

Bolborea M, Vercruysse P, Daria T, Reiners JC, Ouali Alami N, Guillot SJ, Dieterlé S, Sinniger J, Scekic-Zahirovic J, Londo A, Arcay H, Goy MA, Nelson de Tapia C, Thal DR, Shibuya K, Otani R, Arai K, Kuwabara S, Ludolph AC, Roselli F, Yilmazer-Hanke D, Dupuis L.

Acta Neuropathol. 2023 Apr14; 146(6):773-791.

Metabolic alterations precede neurofilament changes in presymptomic ALS gene carriers

Dorst J, Weydt P, Brenner D, Witzel S, Kandler K, Huss A, Herrmann C, Wiesenfarth M, Knehr A, Günther K, Müller K, Weishaupt JH, Prudlo J, Forsberg K, Andersen PM, Rosenbohm A, Schuster J, Roselli F, Dupuis L, Mayer B, Tumani H, Kassubek J, Ludolph AC.

EBioMedicine. 2023 Mar12; 90:104521.

Integrative genetic analysis iluminates ALS heritability and identifies risk genes

Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L.

Nat Commun. 2023 Jan20; 14(1):342.

Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

Li S, Olde Heuvel F, Rehman R, Aousji O, Froehlich A, Li Z, Jark R, Zhang W, Conquest A, Woelfle S, Schoen M, O Meara CC, Reinhardt RL, Voehringer D, Kassubek J, Ludolph A, Huber-Lang M, Knöll B, Morganti-Kossman MC, Brockmann MM, Boeckers T, Roselli F.

Nat Commun. 2023 Jan13; 14(1):200.

2022

Met/HGFR triggers detrimental reactive microglia inTBI

Rehman R, Miller M, Krishnamurthy SS, Kjell J, Elsayed L, Hauck SM, Olde Heuvel F,Conquest A, Chandrasekar A, Ludolph A, Boeckers T, Mulaw MA, Goetz M, Morganti-Kossmann MC, Takeoka A, Roselli F.

Cell Rep. 2022 Dec 27;41(13):111867.

Neuronal nuclear calcium signaling suppression of microglial reactivity ismediated by osteoprotegerin after traumatic brain injury

Fröhlich A, Olde Heuvel F, Rehman R, Krishnamurthy SS, Li S, Li Z, Bayer D, Conquest A,Hagenston AM, Ludolph A, Huber-Lang M, Boeckers T, Knöll B, Morganti-Kossmann MC,Bading H, Roselli F.

J Neuroinflammation. 2022 Nov19;19(1):279.

Shank2/3 double knockout-basedscreening of cortical subregions links the retrosplenial area to the loss of social memory inautism spectrum disorders.

Garrido D, Beretta S, Grabrucker S, Bauer HF, Bayer D, Sala C, Verpelli C, Roselli F,Bockmann J, Proepper C, Catanese A, Boeckers TM.

Mol Psychiatry. 2022 Dec;13(12):4994-5006.

Neurochemical Monitoring of Traumatic Brain Injury by theCombined Analysis of Plasma Beta-Synuclein, NfL, and GFAP in Polytraumatized Patients.

Halbgebauer R, Halbgebauer S, Oeckl P, Steinacker P, Weihe E, Schafer MK, Roselli F,Gebhard F, Huber-Lang M, Otto M.

Int J Mol Sci. 2022 Aug 25;23(17):9639.

Increased NF-L levels in the TDP-43G298SALS mouse model resemble NF-L levels in ALS patients.

Buck E, Oeckl P, Grozdanov V, Bopp V, Kühlwein JK, Ruf WP, Wiesner D, Roselli F,Weishaupt JH, Ludolph AC, Otto M, Danzer KM.

Acta Neuropathol. 2022Jul;144(1):161-164.

Bodyfat compartment determination by encoder-decoder convolutional neural network: applicationto amyotrophic lateral sclerosis.

*Vernikouskaya I, *Müller HP, Felbel D, Roselli F, Ludolph AC, Kassubek J, Rasche V.

Sci Rep. 2022 Apr 1;12(1):5513.

Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated WithFLT3/FLT3L Signaling.

Zhang J, Li Z, Chandrasekar A, Li S, Ludolph A, Boeckers TM, Huber-Lang M, Roselli F*,Olde Heuvel* F.

Front Immunol. 2022 Feb 24;13:824459.

Blood β-Synuclein and Neurofilament Light ChainDuring the Course of Prion Disease.

Halbgebauer S, Abu-Rumeileh S, Oeckl P, Steinacker P, Roselli F, Wiesner D, Mammana A,Beekes M, Kortazar-Zubizarreta I, Perez de Nanclares G, Capellari S, Giese A, Castilla J,Ludolph AC, Žáková D, Parchi P, Otto M.

Neurology. 2022 Feb2:10.1212/WNL.0000000000200002.

2021

Differential effect of ethanol intoxication on peripheralmarkers of cerebral injury in murine blunt traumatic brain injury.

Li Z, Zhang J, Halbgebauer S, Chandrasekar A, Rehman R, Ludolph A, Boeckers T, Huber-Lang M, Otto M, Roselli F*, Heuvel FO*.

Burns Trauma. 2021 Sep30;9:tkab027.

A CRHR1 antagonist preventssynaptic loss and memory deficits in a trauma-induced delirium-like syndrome.

Cursano S, Battaglia CR, Urrutia-Ruiz C, Grabrucker S, Schön M, Bockmann J, Braumüller S,Radermacher P, Roselli F, Huber-Lang M, Boeckers TM.

MolPsychiatry. 2021 Aug;26(8):3778-3794.

Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-AssociatedMicroglia-Like Phenotype Upon Cortical Stab-Wound Injury.

Rehman R, Tar L, Olamide AJ, Li Z, Kassubek J, Böckers T, Weishaupt J, Ludolph A, WiesnerD, Roselli F.

Front Aging Neurosci. 2021 Jul13;13:684171.

Synaptic disruption and CREB-regulated transcription are restoredby K+ channel blockers in ALS.

Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A,Torelli F, Ioannidis V, Lipecka J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Mulaw MA,Roselli F*, Böckers TM*.

EMBO Mol Med. 2021 Jul 7;13(7):e13131.

Disruption of orbitofrontal-hypothalamic projections in a murine ALSmodel and in human patients.

Bayer D, Antonucci S, Müller HP, Saad R, Dupuis L, Rasche V, Böckers TM, Ludolph AC,Kassubek J, Roselli F.

Transl Neurodegener. 2021 May 31;10(1):17.

Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.

Scekic-Zahirovic J, Sanjuan-Ruiz I, Kan V, Megat S, De Rossi P, Dieterlé S, Cassel R, JametM, Kessler P, Wiesner D, Tzeplaeff L, Demais V, Sahadevan S, Hembach KM, Muller HP,Picchiarelli G, Mishra N, Antonucci S, Dirrig-Grosch S, Kassubek J, Rasche V, Ludolph A,Boutillier AL, Roselli F, Polymenidou M, Lagier-Tourenne C, Liebscher S, Dupuis L.

Nat Commun. 2021 May 21;12(1):3028.

Segmental involvement ofthe corpus callosum in C9orf72-associated ALS: a tract of interest-based DTI study.

Müller HP, Lulé D, Roselli F, Behler A, Ludolph AC, Kassubek J.

Ther AdvChronic Dis. 2021 Mar 21;12:20406223211002969.

2020

Ethanol Intoxication Alleviates the Inflammatory Response of RemoteOrgans to Experimental Traumatic Brain Injury.

Xu B, Chandrasekar A, Olde Heuvel F, Powerski M, Nowak A, Noack L, Omari J, Huber-LangM, Roselli F, Relja B.

Int J Mol Sci. 2020 Oct 31;21(21):E8181.

Multiplexedchemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.

Ouali Alami N, Tang L, Wiesner D, Commisso B, Bayer D, Weishaupt J, Dupuis L, Wong P,Baumann B, Wirth T, Boeckers TM, Yilmazer-Hanke D, Ludolph A, Roselli F.

LifeSci Alliance. 2020 Sep 8;3(11):e201900571.

Diffusion Tensor Imaging-Based Studies at theGroup-Level Applied to Animal Models of Neurodegenerative Diseases.

Müller HP, Roselli F, Rasche V, Kassubek J.

Front Neurosci. 2020Aug 31;14:734.

Effect of high-caloric nutrition on serum neurofilament light chain levels in amyotrophic lateral sclerosis.

Dorst J, Schuster J, Dreyhaupt J, Witzel S, Weishaupt JH, Kassubek J, Weiland U, Petri S,Meyer T, Grehl T, Hermann A, Jordan B, Grosskreutz J, Zeller D, Boentert M, Schrank B,Prudlo J, Winkler AS, Gorbulev S, Roselli F, Dupuis L, Otto M, Ludolph AC.

JNeurol Neurosurg Psychiatry. 2020 Sep;91(9):1007-1009.

Autism-associated SHANK3 mutations impairmaturation of neuromuscular junctions and striated muscles.

Lutz AK, Pfaender S, Incearap B, Ioannidis V, Ottonelli I, Föhr KJ, Cammerer J, Zoller M,Higelin J, Giona F, Stetter M, Stoecker N, Alami NO, Schön M, Orth M, Liebau S, Barbi G,Grabrucker AM, Delorme R, Fauler M, Mayer B, Jesse S, Roselli F, Ludolph AC, BourgeronT, Verpelli C, Demestre M, Boeckers TM.

Sci Transl Med. 2020 Jun10;12(547):eaaz3267.

Synaptic Restoration by cAMP/PKA DrivesActivity-Dependent Neuroprotection to Motoneurons in ALS.

Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N,Frankel W, Manuel M, *Roselli F, *Zytnicki D.

J Exp Med. 2020 Aug3;217(8):e20191734.

Focal alterations of the callosal area III in primary lateral sclerosis: An MRI planimetry and textureanalysis.

Müller HP, Dreyhaupt J, Roselli F, Schlecht M, Ludolph AC, Huppertz HJ, Kassubek J.

Neuroimage Clin. 2020 Feb 21;26:102223.

Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis.

Ludolph AC, Dorst J, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Meyer T, Petri S,Hermann A, Emmer A, Grosskreutz J, Grehl T, Zeller D, Boentert M, Schrank B, Prudlo J,Winkler AS, Gorbulev S, Roselli F, Schuster J, Dupuis L; LIPCAL-ALS Study Group.

Ann Neurol. 2020Feb;87(2):206-216.

2019

Longitudinal diffusion tensormagnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosalmicrostructure with spared corticospinal tract in the TDP-43 (G298S) ALS mouse model.

Müller HP, Brenner D, Roselli F, Wiesner D, Abaei A, Gorges M, Danzer KM, Ludolph AC,Tsao W, Wong PC, Rasche V, Weishaupt JH, Kassubek J.

Transl Neurodegener. 2019 Aug 30;8:27.

STAT6 mediates the effect of ethanol on neuroinflammatory response inTBI.

Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P,Sinske D, PalmerA, Wiesner D, Ludolph A, Huber-Lang M, Relja B, Wirth T, Röszer T, Baumann B, BoeckersT, Knöll B, Roselli F.

Brain Behav Immun. 2019 Oct;81:228-246.

TREM1-ors shaking brain and gut upon stroke.

Roselli F, Huber-Lang M.

Nat. Immunol. 2019Aug;20(8):950-952.

Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons throughSQSTM1/p62 accumulation.

Catanese A, olde Heuvel F, Mulaw M, Demestre M, Higelin J, Barbi G, Freischmidt A,Weishaupt JH, Ludolph AC, Roselli F*, Boeckers TM*.

Autophagy, 2019 Apr 2:1-19.

Parvalbumin interneurons shape neuronalvulnerability in blunt TBI.

Chandrasekar A, olde Heuvel F, Tar L, Hageston AM, Palmer A, Linkus B, Ludolph AC, Huber-Lang M, Böckers TM, Bading H, Roselli F.

Cerebral Cortex 2019 Jun 1;29(6):2701-2715

2018

Stage-dependent remodeling of projections to motor cortex in ALSmouse model revealed by a new variant retrograde-AAV9.

Commisso B, Ding L, Varadi K, Gorges M, Bayer D, Boeckers TM, Ludolph AC, Kassubek J,Müller OJ, Roselli F.

Elife. 2018 Aug 23;7.

Nutrient limitation affects presynaptic structures through dissociable Bassoon autophagic degradation and impairedvesicle release.

Catanese A, Garrido D, Walther P, *Roselli F, *Böckers TM.

Journal Cereb Blood Flow Metab 2018 Nov;38(11):1924-1939.

Interferons in Traumatic Brain andSpinal Cord Injury: current evidence for translational application.

Roselli F, Chandrasekar A, Morganti-Kossmann MC.

Front Neurol 2018 Jun19;9:458

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, NettekovenM, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J,Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, *Roselli F, *Baumann B.

EMBO J. 2018 Aug 15;37(16).

The neuroprotective effectof ethanol intoxication in TBI is associated with the suppression of ErbB signaling in PV-positive interneurons.

Chandrasekar A, Olde Heuvel F, Wepler M, Rehman R, Palmer A, Catanese A, Linkus B,Ludolph A, Boeckers T, Huber-Lang M, Radermacher P, Roselli F.

J Neurotrauma. 2018 Nov 15;35(22):2718-2735.

Hypoexcitability precedes denervation in the large fast-contracting motorunits in two unrelated mouse models of ALS.

Martinez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F,Zytnicki D, Manuel M.

eLife. 2018 Mar 27;7.

Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant Mice.

Förstner P, Rehman R, Anastasiadou S, Haffner-Luntzer M, Sinske D, Ignatius A, Roselli F,Knöll B.

J Neurotrauma. 2018 Oct 1;35(19):2317-2329.

Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses.

Chandrasekar A, Aksan B, Heuvel FO, Förstner P, Sinske D, Rehman R, Palmer A, LudolphA, Huber-Lang M, Böckers T, Mauceri D, Knöll B, Roselli F.

Exp Neurol. 2018 Jan 4;302:34-45.

Reversible induction of TDP-43 granules in cortical neurons aftertraumatic injury.

Wiesner D, Tar L, Linkus B, Chandrasekar A, Olde Heuvel F, Dupuis L, Tsao W, Wong PC, Ludolph A, Roselli F.

Exp Neurol. 2018 Jan;299(Pt A):15-25.

Medusa's Head: The Complement System inTraumatic Brain and Spinal Cord Injury.

Roselli F, Karasu E, Volpe C, Huber-Lang M.

J Neurotrauma. 2018 Jan 15;35(2):226-240.

2017

Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.

Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F.

Int Immunopharmacol. 2017 Aug11;51:66-75.

Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI.

Gorges M, Roselli F, Müller HP, Ludolph AC, Rasche V, Kassubek J.

FrontNeurol. 2017 May 10;8:200

2016

Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-β1-40 in Hippocampal Cells.

Li Y, Chang L, Song Y, Gao X, Roselli F, Liu J, Zhou W, Fang Y, Ling W, Li H, Almeida OF, Wu Y.

J Alzheimers Dis. 2016 Aug 1;54(1):135-48.

2015

From Intrinsic Firing Properties to Selective Neuronal Vulnerability inNeurodegenerative Diseases.

Roselli F, Caroni P.

Neuron 2015 Mar 4;85(5):901-910.

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.

Vogl AM, Brockmann MM, Giusti SA, Maccarrone G, Vercelli CA, Bauder CA, Richter JS, Roselli F, Hafner AS, Dedic N, Wotjak CT, Vogt-Weisenhorn DM, Choquet D, Turck CW, SteinV, Deussing JM, Refojo D.

Nat Neurosci. 2015 Feb;18(2):239-51

2014

Modeling Neuronal Vulnerability in ALS.

Roselli F, Caroni P.

Neuron. 2014 Aug 20;83(4):758-760

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